TAILORING THE INTERNAL MICROSTRUCTURE OF THE HYDROGELS BASED ON POLY-HEMA TARGETED FOR DRUG DELIVERY SYSTEMS

1 TRUDICOVA Monika
Co-authors:
1 PAPEZIKOVA Hana 1 SEDLACEK Petr 1 PEKAR Miloslav
Institution:
1 Brno University of Technology, Faculty of Chemistry, Brno, Czech Republic, EU, xctrudicova@fch.vut.cz
Conference:
13th International Conference on Nanomaterials - Research & Application, Orea Congress Hotel Brno, Czech Republic, EU, October 20 - 22, 2021
Proceedings:
Proceedings 13th International Conference on Nanomaterials - Research & Application
Pages:
280-285
ISBN:
978-80-88365-00-6
ISSN:
2694-930X
Published:
22nd November 2021
Proceedings of the conference were published in Scopus.
Metrics:
601 views / 382 downloads
Abstract

Transport and barrier properties are important material characteristics in terms of the development of the targeted drug delivery systems. Therefore, this work focused on the study of the possibility of influencing these properties and internal architecture in a model hydrogel system formed by a semi-interpenetrating polymer network with an incorporated polyelectrolyte component. Due to its application potential and its extensive use in medicine, poly(2-hydroxyethyl methacrylate) was chosen as the model hydrogel system for this work. Sodium polystyrene sulfonate was used as the interpenetrating linear polymer. Scanning electron microscopy was used to examine the structure of the three-dimensional hydrogel network. Transport properties were monitored by diffusion tests. Furthermore, diffusion through the hydrogel (barrier properties) was monitored using diffusion cells (Franz cells, horizontal cells). The usability of the semi-interpenetrating polymer network concept for the preparation of materials with tunable relevant properties was confirmed on the proposed materials.

Keywords: Hydrogel, poly(2-hydroxyethyl methacrylate), transport properties, drug delivery systems

© This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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