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BIOLOGICAL EFFECTS OF METAL NANOPARTICLES AFTER EXPOSURE OF MAMMALIAN CELLS

1 HENDRICKSON Olga D.
Co-authors:
2 PUKHOV Sergey a. 1,2 ZHERDEV Anatoly V.
Institutions:
1 Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Leninsky prospect 33, Moscow 119071, Russia, odhendrick@gmail.com
2 Institute of Physiologically Active Compounds, Russian Academy of Sciences, Severny proezd 1, Chernogolovka 142432, Moscow region, Russia, zherdev@inbi.ras.ru
Conference:
11th International Conference on Nanomaterials - Research & Application, Hotel Voronez I, Brno, Czech Republic, EU, October 16th - 18th 2019
Proceedings:
Proceedings 11th International Conference on Nanomaterials - Research & Application
Pages:
520-525
ISBN:
978-80-87294-95-6
ISSN:
2694-930X
DOI:
https://doi.org/10.37904/nanocon.2019.8495
Published:
1st April 2020
Proceedings of the conference were published in Web of Science and Scopus.
Metrics:
717 views / 353 downloads
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Abstract

Investigations of the biological effects of nanomaterials are important for assessing the risk of nanotechnology products. The present study includes the comparative investigation of the localization of core-shell gold hybrid nanostructures and native titanium dioxide nanoparticles. Changes in biochemical parameters of the treated rats in comparison to control animals were observed depending on the type of nanoparticles used. The exposure did not cause lethality, substantial behavior deviations, water and food consumption, pathomorphology of the internal organs. Besides, this study includes the investigation of biological effects of metal nanoparticles after exposure of mammalian cells. Dose- and time-dependent changes in cell viability after exposure to gold hybrid nanostructures and native titanium dioxide nanoparticles were estimated by MTT test.

Keywords: Metal nanoparticles, in vitro toxicity, cell viability, MTT-test

© This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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