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MOLECULARLY IMPRINTED POLYMERS ON THE SURFACE OF MAGNETIC NANOPARTICLES FOR SELECTIVE SEPARATION AND DETECTION OF NUCLEOBASES

1 ZEMANKOVA Kristyna
Co-authors:
1,2 BEZDEKOVA Jaroslava 3 VODOVA Milada 1,2 VACULOVICOVA Marketa
Institutions:
1 Department of Chemistry and Biochemistry, Faculty of AgriSciences, Mendel University in Brno, Zemedelska 1, CZ-613 00 Brno, Czech Republic, EU, E-mail: zemankova.kristyna@seznam.cz
2 Central European Institute of Technology, Brno University of Technology, Purkynova 123, CZ-612 00 Brno, Czech Republic
3 Faculty of Chemistry, Brno University of Technology, Purkynova 118, 612 00, Brno, Czech Republic
Conference:
11th International Conference on Nanomaterials - Research & Application, Hotel Voronez I, Brno, Czech Republic, EU, October 16th - 18th 2019
Proceedings:
Proceedings 11th International Conference on Nanomaterials - Research & Application
Pages:
442-445
ISBN:
978-80-87294-95-6
ISSN:
2694-930X
DOI:
https://doi.org/10.37904/nanocon.2019.8567
Published:
1st April 2020
Proceedings of the conference were published in Web of Science and Scopus.
Metrics:
812 views / 384 downloads
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Abstract

Nucleobases are the main building blocks in DNA and RNA playing very important roles in cell metabolism. Changes of bases in DNA sequence may affect function of products of gene expression – proteins, and this can lead to inherited diseases and most human cancer types. Pharmacological studies, clinical diagnosis and others areas need a quick, inexpensive and exact method for determination of nucleobases. In this work, we explore the possibility of improving detection of nucleobases by using capillary electrophoresis in combination with isolation by magnetic particles modified by molecularly imprinted polymer.

Keywords: Capillary electrophoresis, nucleobases, magnetic particles, molecularly imprinted polymers

© This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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