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NANOPARTICLES BASED ON STAR-SHAPED CARBOXY-TERMINATED POLYLACTIDE AND CHITOSAN FOR CONTROLLED RELEASE APPLICATIONS

1 Di Martino Antonio
Co-authors:
1 Kucharczyk Pavel 1 Sedlarik Vladimir
Institution:
1 Centre of polymer systems, University Institute, tr.T. Bati 5678, 76001 Zlin, Czech Republic
Conference:
7th International Conference on Nanomaterials - Research & Application, Hotel Voronez I, Brno, Czech Republic, EU, October 14th - 16th 2015
Proceedings:
Proceedings 7th International Conference on Nanomaterials - Research & Application
Pages:
394-398
ISBN:
978-80-87294-59-8
ISSN:
2694-930X
Published:
11th January 2016
Proceedings of the conference were published in Web of Science and Scopus.
Metrics:
495 views / 189 downloads
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Abstract

In this work chitosan based nanoparticles were prepared and modified by a star-shaped carboxy-terminated polylactide (S-PLA) in order to reduce the doxorubicin burst effect in physiological solution.S-PLA was prepared by polycondensation reaction using pentetic acid as a core molecule and methansulfonic acid as catalyst and linked to chitosan backbone through coupling reaction. Afterwards, chitosan-(S-PLA) modified nanoparticles loaded with doxorubicin were prepared by polyelectrolytes complexation method using dextran sulphate sodium salt as polyanion.Results show nanoparticles with diameter in the range 100-200 nm, spherical shape and ζ-potential between 27-35 mV. The presence of (S-PLA) side chain does not influence the encapsulation efficiency of the drug but strongly reduce the initial burst effect compared with unmodified chitosan.

Keywords: burst effect, drug delivery, chitosan, polylactide, doxorubicin

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